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Wikipedia - Fulvestrant

Fulvestrant
Systematic (IUPAC) name
13-methyl-7-[9-( 4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]- 7,8,9,11,12,13,14,15,16, 17-decahydro- 6H-cyclopenta[a] phenanthrene-3,17-diol
Identifiers
CAS number 129453-61-8
ATC code L02BA03
PubChem CID 104741
IUPHAR ligand ID 1015
DrugBank APRD00654
Chemical data
Formula C32H47F5O3S 
Mol. mass 606.772 g/mol
Pharmacokinetic data
Protein binding 99%
Half-life 40 days
Therapeutic considerations
Pregnancy cat. D
Legal status Rx only
Routes Intramuscular injection
 YesY(what is this?)  (verify)

Fulvestrant, also known as ICI 182,780, is a drug treatment of hormone receptor-positive metastatic breast cancer in postmenopausal women with disease progression following anti-estrogen therapy. It is an estrogen receptor antagonist with no agonist effects, which works both by down-regulating and by degrading the estrogen receptor.[1] It is administered as a once-monthly injection.

Fulvestrant is marketed by AstraZeneca with the brand name Faslodex.

[edit] Clinical uses

Fulvestrant is a Selective Estrogen Receptor Down-Regulator (SERD). Fulvestrant is indicated for the treatment of hormone receptor positive metastatic breast cancer in postmenopausal women with disease progression following anti-estrogen therapy.

[edit] External links


[edit] References

  1. ^ S. Kansra, S. Yamagata, L. Sneade, L. Foster & N. Ben-Jonathan, 2005. "Differential effects of estrogen receptor antagonists on pituitary lactotroph proliferation and prolactin release." Mol Cell Endocrinol. 2005 Jul 15;239(1-2):27-36.
v • d • e
Estrogens and progestogens (G03C-D)
Progestogens/
progestins
(progesterone)
Agonist
Other/
ungrouped
Antiprogestogen/
SPRM
Estrogens
Agonist
#WHO-EM. ‡Withdrawn from market. CLINICAL TRIALS: †Phase III. §Never to phase III

Fulvestrant(129453-61-8)

Synonyms:Fulvestrant(129453-61-8),(7a,17b)-7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol

Molecular Structure:

CAS NO.: 129453-61-8

COA Appearance:White to Off-white crystalline powder Loss on Drying:0.5%(max) Residue On Ignition:0.1% Heavy Metals:10ppm Single Impurity:0.3%(Max) Total Impurity:1.0%(Max)

Package:1g/bag /according to customer request Usage:Fulvestrant(129453-61-8) used as Antineoplastic agents, API

Instcok

Retrieved from "http://en.wikipedia.org/wiki/Fulvestrant"

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Fulvestrant".

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